Here are some basic facts of biochemistry from MBoC4:
Spring 2008 Thursdays from 4:00 to 4:50 pm in room 5 of the
main physics building on
Lomas near Yale:
Our e-mail addresses are sjkoch@unm.edu, jthomas@unm.edu, klidke@unm.edu, and
cahill@unm.edu. See also Koch's OpenWetWare
site.
Some notes on mathematics are available on-line;
chapter 12 discusses probability and Lengevin's theory of diffusion and
brownian motion. You may find there a simple derivation of
Einstein's relation D = b k T
in which D is the diffusion
constant and b the mobility,
which is the inverse of the viscous-friction coefficient.
The book Molecular
Biology of the Cell, Fifth Edition by Bruce Alberts,
Alexander Johnson, Julian Lewis, Martin Raff, Keith Roberts, and Peter
Walter is a wonderful source of background material
for any course on biophysics.
But it is very long and amounts to an
undergraduate curriculum in molecular and cell biology.
So it is not required for this course. You can read
it online thru the PubMed
site Molecular
Biology of the Cell.
Some basic facts of biochemistry appear
after the list of talks.
Students
are encouraged to ask all sorts of questions during the talks.
With tentative titles in italics,
the talk schedule so far is:F
24 January, Remarks
on medicinal chemistry and on the rule of 5
by Christopher Kipinski in the auditorium of tht Domenici Center.
31 January, "Elements of Brownian Motion" by Kevin
Cahill
(physics).
7 February, Saliant
points of the 52d annual meeting of the Biophysical Society reported by
Cahill, Lidke, and Lidke with incisive remarks by Thomas. Kornberg's paper on the trigger loop of the
DNA and RNA polymerases.
Friday 15 February, "Probing the Very Small in
Biology! Mechanical Unfolding and Refolding of Protein Domains" by Evan Evans (B.U. & U.B.C.)
at 2 pm in room 101 of CHTM, which is 338 on map.
Abstract of his talk.
21 February, "Fluctuation and Dissipation" by
Kevin Cahill
(physics).
28 February, "Something by" Diane Lidke (UNM Medical School)
6 March, "Something by" Keith
Lidke (physics)
13 March, on the Quake paper by Steve Koch (physics)
20 March, Spring Break, no seminar.
Many dates remain open:
27 March, "How to Make Optical Tweezers" by Steve Koch (physics)
3 April, "Something by" James Thomas (physics)
10 April, "Cold-inducible RNA binding protein's
role in breast cancer" by Rebecca Hartley (Cell Biology and
Physiology)
17 April, "Something by" David Bear (Cell
Biology and
Physiology). Rebecca Hartley says Bear "knows everything."
24 April, "Technologies
and Challenges in Gene Expression and Genomics"
by Scott Ness (Molecular Genetics & Microbiology)
1 May,
8 May,
What follows is from a previous semester.
1 March,"Protease-Mediated
Blood-Brain Barrier Injury in Stroke and Vascular Dementia," Professor
Gary A. Rosenberg (neurology) A recent paper by
him on proteins that use metal ions to cut other proteins.
8 March, "Microscope Optics and Phase-Contrast Microscopy," Professor
James Thomas (physics).
15 March, Spring Break, no class
22 March, "Nuclear-Resonance Single-Cell
Detection," Professor
Laurel Sillerud
(biochemistry and molecular biology)
29 March, "Smart Drugs," Kevin Cahill (physics), pdf of talk. Two questions and two answers.
5 April, "DNA Packing Pressure in vitro vs. in viro,"
Dr. Adrian Parsegian, Laboratory of
Physical and Structural Biology
of NICHD, NIH.
12 April, "RNA
Interference," Professor Rebecca
Hartley (cell biology and physiology), ppt of talk.
19 April, "Synthetic Polymers for Tissue
Engineering," Professor Elizabeth Dirk (chemical
&
nuclear engineering), abstract of talk.
26 April, "OPMD: A Complex Genetic Disease of
Protein Aggregation," Professor
David Bear (cell
biology and physiology); students should read chapter 6 of Molecular Biology of the Cell which
is available on
line.
3 May, "Cytometry,"
Dr. James Jett (LANL)
10 May, Short talks by graduate students and
eager
undergraduates.
Here are some basic facts of biochemistry from MBoC4: